Luise Wolfram grew up in Jena. From 2002 to 2005 she was a member of the theatre group of the Music and Art School Jena. She graduated from high school in 2006. From 2006 to 2010 Luise Wolfram studied at the State Academy of Dramatic Arts"Ernst Busch" Berlin. Her final production seductibility on both sides took place at the bat-studiotheater under the direction of Matthias Günther. After graduating, she received an offer from the Schaubühne at Lehniner Platz. From 2010 to 2015 she was part of the permanent ensemble. She has been working as a freelancer since 2015; however, she still performs at the Berlin Schaubühne. Her aunt is the actress Claudia Geisler.